This design guide is intended for laboratory-type facilities, such as those found in universities, and for commercial and industrial research facilities, including laboratories and cleanrooms. These facilities typically have Uniform Building Code (UBC) occupancy classifications of B, H-8, or H-7. When we use the word "cleanroom," we mean a research and not a production scale facility. We anticipate that future versions of this guide will cover related production and manufacturing-scale laboratory-type facilities. We remind the reader that this guide is intended to complement existing laboratory design manuals and references by describing the ramifications of Energy Efficiency Measures (EEMs) that could be incorporated. This guide does not provide calculation methods to determine energy savings of a design. However, references to in-depth calculation procedures are given.