The Handbook of Facilities Planning (1990) points out some issues in high-velocity cleanroom design.
A high velocity system can create turbulence, which will influence the air flow and the conservation of energy. The condition of the filters, the lights in the ceiling, and the fans and motors must all be considered in the selection of a high velocity air system. Because the filters determine the pattern of the air flow, the lights can create a void in the air-flow pattern and the use of high-volume fans and motors increases installation, operating and maintenance costs. A low velocity system with proper lighting, filters and plenum is suitable for some manufacturers. However, any manufacturer needing a cleanroom with a Class 10 or even Class 100 may not be able to utilize a low velocity system.
